Production Processes of Pipette Tips

Pipette tips are a ubiquitous consumable in laboratories, necessitating precise dimensional accuracy and concentricity. Smooth inner walls, free from flow marks, along with notch and burr-free tips, are essential. Precautions for their production include:

1. Production Environment

Pipette tips are critical components used in molecular detection, in vitro diagnosis, and various experiments, demanding stringent environmental conditions during production. Any foreign biological contamination on the surface of the pipette tip could directly impact analysis results. Currently, a Class 100,000 dust-free workshop is commonly utilized to maintain cleanliness.

2. Equipment Selection

Selecting the appropriate equipment is crucial due to the intricate nature of pipette tips, characterized by multiple cavities, deep recesses, thin walls, and rapid molding cycles. Optimal equipment must exhibit high molding efficiency, a low failure rate, and sustained stability. Therefore, high-speed electric injection molding machines are preferred for their:

(1). Ability to meet the precision requirements of thin-walled products, reducing stress during molding and enhancing the straightness of pipetting tips.
(2). Rapid and precise mold opening and closing, ensuring stable positioning for automatic manipulators to retrieve products.
(3). Excellent stability and repeatability, facilitated by independent motor control systems, allowing simultaneous movement if permitted by the mold design.


3. Key Considerations

Common defects in pipette tips include insufficient material in the tip, bending, burrs at the tip and mouth, and dimensional instability. To address these issues effectively, the following points should be carefully considered during the production process:

Injection Speed Optimization Achieving a balance in injection speed is crucial. Excessively high speeds can trap gas within the pipette tip, resulting in material shortage, while overly slow speeds can lead to significant internal stress, causing bending and insufficient straightness. It's advisable to gradually increase injection speed while closely monitoring mold and product conditions.

Raw Material Selection

(1). Opt for materials with excellent fluidity to ensure swift filling and minimize the risk of poor appearance. Verifying basic parameters is essential to achieve optimal results.

(2). Maintain a suitable material temperature: Polypropylene (PP) materials are crystalline, and temperature control is vital. Too low a temperature can lead to slow crystallization, resulting in foggy, opaque products prone to brittleness. Conversely, excessively high temperatures can degrade the raw material, compromising product strength.

Reasonable V/P Switching

Implementing a sensible V/P (Velocity to Pressure) switching strategy is crucial for maintaining a balanced glue feed and ensuring product adjustment. It's essential to initiate adjustments from short shots and gradually progress to full filling. When dealing with short shot products, meticulous observation of pipette tip balance and filling eccentricity is necessary. Designing a rational V/P switch helps prevent issues such as material shortage, burrs, and inadequate straightness in pipette tips.

Automation

(1). Pipetting Automation: Install a negative pressure gauge to monitor vacuum changes during automatic pipetting actions. Establishing a reasonable vacuum range and integrating it with equipment allows for mold protection and facilitates auxiliary detection of product damage during abnormal operations.

(2). Sufficient Air Volume: Ensure the suction fixture plate has ample air volume by selecting larger pipes whenever possible, while still considering spatial constraints.

(3). Cushioned Fixture Design: Incorporate plastic with cushioning structures into the fixture body design as much as possible to enhance durability and minimize damage risk.

 

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